Strategies to tackle SARS-CoV-2 Mu, a newly classified variant of interest likely to resist currently available COVID-19 vaccines현재 사용 가능한 COVID-19 백신에 저항할 가능성이 있는 새로 분류된 관심 변종인 SARS-CoV-2 Mu에 대처하기 위한 전략Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adopted approach B.1 lineage B.1.621 BNT161b2 booster dose Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine development Evidence exacerbated Genetic genomic Genomic surveillance global mass vaccination Health implementation infections Intervention Lineage mass vaccination Mu variant mutations Neutralizing non-pharmaceutical interventions (NPIs) NPIs potential risk public health measure public health measures Recombination reported required respiratory restrict SARS-CoV-2 SARS-CoV-2 B.1.621 SARS-CoV-2 virus sera shown Strains Strategy sub-lineage B.1.621.1 Surveillance survivor the SARS-CoV-2 virus therapeutic threat vaccination Vaccine vaccine breakthrough. Vaccine development variant variants [DOI] 10.1080/21645515.2022.2027197 PMC 바로가기 [Article Type] Article
Molecular characterization and sequecing analysis of SARS-CoV-2 genome in Minas Gerais, BrazilArticle Published on 2022-10-012023-07-10 Journal: Biologicals : journal of the International Associa [Category] COVID19(2023년), [키워드] B.1 lineage COVID-19 Genome sequencing Genomic surveillance Minas Gerais SARS-CoV-2. [DOI] 10.1016/j.biologicals.2022.08.001 PMC 바로가기
Phylogenomic analysis of the monkeypox virus (MPXV) 2022 outbreak: Emergence of a novel viral lineage?Article Published on 2022-09-012022-11-15 Journal: Travel medicine and infectious disease [Category] 진단, [키워드] affecting Analysis B.1 B.1 lineage characterized clade clinical manifestation community transmission confirmed case COVID-19 pandemic demonstrated determine driver emergence epidemiological Europe Evolution exceptional Factor generate Genome genomic globe help humans include information lineage B.1 measure mitigate Monkeypox Monkeypox virus multifactorial outbreak pathogen performed phylogenomic analysis. public health Region reported resource Spread Surveillance sustained Transmission dynamics unique vaccination virus zoonotic disease [DOI] 10.1016/j.tmaid.2022.102402 PMC 바로가기
Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] association B.1 lineage candidate gene case-control study CCL2 cohort of patient contribute COVID-19 COVID-19 case COVID-19 severity Cytokine storm examined genetic loci genetic marker Genetic variant Genome Genome-wide association study genotyped Germany GWAS healthy control Hospitalization Hospitalized Host Host genetic factor host genetics investigated Lineage LZTFL1 MOST objective Pathogenesis patients with COVID-19 phenotype Phylogeny polygenic risk score predict reached reconstructed Result risk risk score SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 strain sequenced severity severity of COVID-19 significantly single nucleotide polymorphisms susceptibility the SARS-CoV-2 genome variant with COVID-19 [DOI] 10.1016/j.ijid.2022.06.030 [Article Type] Research article
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particlesOmicron 돌연변이는 SARS-CoV-2 바이러스 유사 입자의 감염성을 높이고 항체 중화를 감소시킵니다.Article Published on 2022-08-022022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antibody neutralization Antisera assembly B.1 B.1 lineage B.1.1 bebtelovimab Casirivimab Cell cell entry change convalescent sera coronavirus COVID-19 Delta detectable detrimental dose Effect Efficacy Efficiency eight eight subject elicited ENhance examined Imdevimab individual Johnson & Johnson Johnson & Johnson luciferase Moderna monoclonal antibodies monoclonal antibody Mutation N proteins neutralization neutralization activity neutralization titer Neutralizing antibodies neutralizing antibody omicron Omicron variant Patient Pfizer Pfizer/BioNTech Prevent property reduce reduced respiratory resulting robust SARS-CoV-2 SARS-CoV-2 variant sequence sera severe acute respiratory syndrome Coronavirus Spike protein Spread structural protein structural proteins subjects survivor Vaccine Vaccines variant variants Viral viral infectivity Virus-like particle virus-like particles virus-like particles. VLP VLPs [DOI] 10.1073/pnas.2200592119 PMC 바로가기 [Article Type] Article
Temporal lineage replacements and dominance of imported variants of concern during the COVID-19 pandemic in Kenya Research Published on 2022-08-012022-10-05 Journal: Communications Medicine [Category] 진단, 치료기술, [키워드] Analysis B.1 B.1 lineage B.1.1 Beta circulating variant COVID-19 epidemic COVID-19 pandemic Delta disease severity dominant European expand FIVE Genome genomes highlight Interpretation Kenya Lineage omicron phenotype remained Result SARS-CoV-2 lineage subsequent Surveillance Temporal Transmissibility Vaccine variant variants of concern virulence VoC Wave [DOI] 10.1038/s43856-022-00167-8 [Article Type] Research
The phylodynamics of SARS-CoV-2 during 2020 in Finland Research Published on 2022-06-102022-10-05 Journal: Communications Medicine [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome analyses analysis B.1 lineage Bayesian caused circulating collected coronavirus country D614G mutation early stage Effect European fatality Finnish Google mobility data incidence independent Infection Intervention investigated Italy Lineage pandemic prevalent public health measures replaced Result SARS-CoV-2 SARS-CoV-2 lineage sequence sequenced Spain Spread strain subsequent suggested virus virus genome [DOI] 10.1038/s43856-022-00130-7 [Article Type] Research
Differential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing Mice인간 ACE2-발현 마우스에서 우려되는 SARS-CoV-2 변이체의 차별적 병인 발생Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2-expressing mice acute respiratory syndrome acute respiratory syndrome coronavirus Alpha B.1 B.1 lineage B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Brain caused chemokine chemokines circulating circulating variant Clinical sign concern contagious coronavirus COVID-19 cytokine Cytokines death evaluated exhibited hACE2 Human Infection Inflammation inoculated intranasally K18-hACE2 K18-hACE2 mice less lineages lung Lungs mice mouse-adapted SARS-CoV-2 omicron Omicron. pandemic Pathogenesis pathogenesis of SARS-CoV-2 question Replication resulting SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity significantly significantly higher significantly lower significantly more survival rate the disease Transcription variant variants of concern virus virus virus titer [DOI] 10.3390/v14061139 PMC 바로가기 [Article Type] Article
Whole-genome analysis of SARS-CoV-2 in a 2020 infection cluster in a nursing home of Southern Italy남부 이탈리아 요양원의 2020년 감염 클러스터에서 SARS-CoV-2의 전체 게놈 분석Article Published on 2022-04-012022-09-12 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Analysis analyzed association B.1 lineage Calabria carried clade clinical parameter Cluster COVID-19 D614G Evolution Frequency Genome Haplotype haplotypes help hotspot indicated Infection initial investigated IQ-TREE Italy NC_045512.2 next generation sequencing NGS nursing home outbreak Pandemics Patient patients predominant responsible SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2. sequence single nucleotide variation SNV SNVs South Spread Swab UTR viral genome viral spread viral strain Viral transmission [DOI] 10.1016/j.meegid.2022.105253 PMC 바로가기 [Article Type] Article
From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer사슴에서 사슴으로: SARS-CoV-2는 효율적으로 전염되며 흰꼬리사슴의 광범위한 조직 친화성과 복제 부위를 나타냅니다.Article Published on 2022-03-212022-09-11 Journal: PLoS Pathogens [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added age Americas B.1 lineage causative agent Central nervous system Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deer demonstrated disease disease control effective host range humans hunting implementation infect Infection Infectious virus intranasal investigated lack lymphoid Measures nasal natural infection Odocoileus Prevent provide replication site reported reservoir SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown susceptible tissue tropism tissues Transmission Transmission dynamics transmitted tropism Viral load virus virus replication white-tailed deer wild animal zoonotic transmission [DOI] 10.1371/journal.ppat.1010197 PMC 바로가기 [Article Type] Article